Neuroimmune Modeling & Discovery
Modulo Bio is a neuroimmunology company that harnesses the power of machine learning, patient iPSC derived cellular modeling and large scale CRISPR screening to develop therapies for neurodegenerative diseases like ALS and Frontotemporal dementia that currently have no effective treatments. Our team specializes in integrating powerful tools like stem cell engineering, multiomics data analysis, and high-throughput automation to discover and modulate neural cells into disease-context and patient-specific protective states.
Modulo Bio is seeking a Stem Cell Scientist to develop and scale an induced-pluripotent stem cell (iPSC)-based in vitro model of the neuroimmune system. Modulo Bio is building a proprietary immune cell modeling platform, which incorporates human genetics, functional genomics, molecular biology, cellular and tissue profiling, disease model engineering, and advanced computational models.
The successful candidate will build a complex cell model platform with the goal of improving our understanding of human biology and therapeutic interventions to inform early and late stage pipeline efforts. Candidates with an eagerness to work within a highly leveraged, team-driven, dynamic research environment will be prioritized. The candidate will work in close collaboration with our internal Computational Biology group which is focused on next-generation sequencing (NGS), functional genomics, cell or tissue profiling, and bioinformatics analyses of cutting-edge large-scale genetic screening or single-cell technologies to enhance our analytic capabilities and to reveal the underlying mechanisms of human disease.
Expertise developing and/or applying iPSC in vitro systems is critical. Cell line and organoid experience is a plus. Practical experience with in vitro model development for neurodegeneration, neurological disorders, or regenerative medicine is desirable.
MS or PhD in Genetics, Molecular Biology, Developmental Biology, Biochemistry, Regenerative Medicine, Neuroscience, or related field
1+ year(s) experience establishing disease models from human iPSCs; hands-on experience with co-cultures preferred
Experience with cellular reprogramming highly desirable
Experience developing or analyzing single cell assays (scRNA-seq, scATAC-seq, spatial transcriptomics, etc.) is advantageous
Sustained, impactful record of scientific contributions and documented evidence of iPSC-related expertise, as evidenced by publications, patents, and presentations
Demonstrated leadership capability both within and across teams
Exceptional organizational and communication skills
iPSC maintenance, differentiation, and co-culturing protocols
Stem cell model assay development and optimization
Regular and effective communication and collaboration with science and technology teams
Incorporate state-of-the-art screening, imaging, and/or automation solutions for stem cell culture and method development